Valvular & structural heart diseaseCohort study
Timing of Noncardiac Surgery Following Transcatheter Aortic Valve Replacement
- Retrospective cohort study
- Nationwide Readmissions Database 2016 to 2020
- multivariable regression
Authors' conclusion
NCS within 30, 31 to 60, or 61 to 90 days after TAVR was not associated with increased odds of MAEs compared with operations after 90 days irrespective of NCS risk category or elective status.
Study context
- Population
- Adults with isolated transcatheter aortic valve replacement (TAVR) for AS who underwent noncardiac surgery (NCS) on a subsequent admission
- Participants
- 3,098 adults
- Exposure
- NCS at ≤30, 31 to 60 or 61 to 90 days vs >90 days after TAVR
- Outcome
- Perioperative major adverse events (MAEs)
Main finding
As reported in the abstract
MAEs
Each group vs >90 daysAdjusted odds ratio (95% CI)
≤30 days
1.05(0.74–1.50)
31 to 60 days
0.97(0.71–1.31)
61 to 90 days
0.95(0.67–1.34)
Observational data: associations, not effects.
Further findings
Risk-adjusted MAE rates by elective status and NCS risk category (average marginal effect)
- Statistically similar across Δt groups
Original publication
Timing of Noncardiac Surgery Following Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 19 June 2024. doi:10.1016/j.jcin.2024.04.049
Summarised from the published abstract; every number is checked against it