Heart failure & cardiomyopathiesSecondary analysis
Timing-specific factors associated with early, intermediate, and late readmission after heart failure hospitalization
- secondary analysis
- single-centre Chinese heart failure cohort
Authors' conclusion
Associated factors differed across post-discharge intervals but overlapped. Early readmission was associated with advanced heart failure severity and cardiorenal-electrolyte instability. Intermediate readmission was associated with haemodynamic compromise and cardiac stress. Late readmission demonstrated stronger associations with chronic comorbidity burden, alongside cognitive and systemic disease. Biventricular heart failure was associated with all three intervals. These findings require external validation.
Study context
- Population
- Patients discharged alive after heart failure hospitalizationpatients discharged alive
- Participants
- 1,992 patients
- Comparison
- Early readmission vs Intermediate readmission vs Late readmission
- Early readmissionn = 140
- Intermediate readmissionn = 358
- Late readmissionn = 278
Primary result
As reported in the abstract
- Readmitted within 6 months
- 776 patients (39.0%)
Further findings
Factors associated with early readmission · ≤28 days
- biventricular heart failure, odds ratio
- 1.72; P = .022
- New York Heart Association class IV
- 1.47; P = .043
- estimated glomerular filtration rate <60 ml/min/1.73 m²
- 1.64; P = .021
- hyponatraemia
- 1.71; P = .008
Factors associated with intermediate readmission · 29-90 days
- biventricular heart failure
- 1.68; P < .001
- systolic blood pressure <110 mmHg
- 1.68; P < .001
- B-type natriuretic peptide ≥1000 pg/ml
- 1.32; P = .029
Factors associated with late readmission · 91-180 days
- dementia
- 2.30; P < .001
- biventricular heart failure
- 1.69; P = .002
- chronic kidney disease
- 1.56; P = .030
- diabetes
- 1.44; P = .043
Model discrimination (apparent area under the curve)
- Early readmission
- 0.677
- Intermediate readmission
- 0.641
- Late readmission
- 0.629
- apparent
Original publication
Summarised from the published abstract; every number is checked against it