A pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study
Pooled result · Trial-defined major adverse cardiovascular events (MACEs) (primary efficacy endpoint)Result — go to the resultIncidence rate ratio 0.92 95% CI 0.86–0.98Authors' conclusion
In secondary prevention for MI, anti-inflammatory therapy significantly reduces MACE without increasing serious adverse events, but it is associated with an increased risk of gastrointestinal adverse events.
Study context
- Population
- Patients receiving anti-inflammatory therapy for secondary prevention after myocardial infarction (MI)patients in twenty-eight studies, mean follow-up of 11 months
- Participants
- 44,406 patients
- Comparison
- Anti-inflammatory therapy compared to control
- Outcome
- Trial-defined major adverse cardiovascular events (MACEs) (primary efficacy endpoint)
Methodological detailsRandomized trials, interaction analyses for drug type and timing of administration, sensitivity and meta-regression analyses
- Randomized trials
- Interaction analyses for drug type and timing of administration
- Sensitivity and meta-regression analyses
Pooled result
As reported in the abstract
Incidence rate ratio
0.92
95% CI 0.86–0.98
Anti-inflammatory therapyvs control
IRR 0.92 (95% CI 0.86–0.98)
Further pooled results
Serious adverse events (primary safety endpoint)
- Anti-inflammatory therapy did not increase serious adverse events
Interaction between effects on MACE and timing of administration
- No significant interaction observed
Safety
| Outcome | IRR (95% CI) | |
|---|---|---|
| Gastrointestinal adverse eventsHigher incidence with anti-inflammatory therapy | 1.21 (1.07–1.36) | |
| 0.512Incidence rate ratio (log scale) |
Original publication
A pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study. Eur Heart J Cardiovasc Pharmacother. Published 3 January 2025. doi:10.
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