Coronary disease & ACSResearch article
Tumor Necrosis Factor Receptor (TNFR) Pathway-Related Proteins and Recurrent Coronary Artery Disease Events
- Cox proportional hazards regression
- UK Biobank
- baseline Olink plasma proteomic measures
Authors' conclusion
Although TNFR1 and TNFR2 were initially thought to have opposing roles in cardiac remodeling postmyocardial infarction, this study highlights the complex interaction between these pathways and the need to identify specific inflammation-related targets to therapeutic strategies.
Study context
- Population
- Participants in the UK Biobank with baseline Olink plasma proteomic measures and CADparticipants with baseline Olink plasma proteomic measures and CAD
- Participants
- 1,009 participants
- Comparison
- Association between proteins measured and recurrent CAD events in follow-up
Main finding
As reported in the abstract
Recurrent CAD events · 11.40 (IQR: 8.00-14.69) years of follow-up
Participants with recurrent CAD events
656 (65.01%)
Further findings
Proteins associated with recurrent CAD events
- Proteins tested
- 1,463
- Proteins independently associated with recurrent CAD events
- 102
Molecular function enrichment for TNFR activity
- Enrichment for tumor necrosis factor receptor (TNFR) activity
- 100-fold (P = 6.37 × 10-10)
TNF-related proteins and recurrent CAD events
- Tumor necrosis factor-alpha risk estimate
- 1.36 (95% CI: 1.17-1.57; P = 6.38 × 10-5)
- TNFR1 (TNFRSF1A) risk estimate
- 1.73 (95% CI: 1.43-2.09; P = 1.23 × 10-8)
- TNFR2 (TNFRSF1B) risk estimate
- 1.27 (95% CI: 1.13-1.44; P = 9.15 × 10-5)
- Of the 16 proteins related to TNF annotated by the Gene Ontology database
Baseline characteristics · enrollment
- Mean age
- 62.51 years (SD 5.94)
- Females
- 183 (18.14%)
Original publication
TNFR Pathway-Related Proteins and Recurrent Coronary Artery Disease Events. JACC Adv. Published 19 March 2026. doi:10.1016/j.jacadv.2026.102687
Summarised from the published abstract; every number is checked against it