Cross-sectional study
Too Little of a Good Thing
- Cross-sectional study
Authors' conclusion
A small ventricle is strongly associated with low CRF because of the combined effect of a smaller resting stroke volume and an attenuated capacity to increase with exercise.
Study context
- Population
- Healthy women aged >30 years (51 ± 9 years)
- Participants
- 185 women
- Exposure
- Quartiles of resting left ventricular end-diastolic volume (LVEDV)
- Outcome
- Association between cardiorespiratory fitness (CRF) (Vo2peak) and ventricular size and function (cardiac magnetic resonance (CMR), echocardiography)
Main finding
As reported in the abstract
Association of Vo2peak with ventricular size and function
Vo2peak strongly associated with resting LVEDV and RV end-diastolic volume (R2 = 0.58-0.63)
P < 0.0001
Vo2peak weakly associated with resting left ventricular (LV) systolic and diastolic function (R2 = 0.01-0.06)
P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | Q1 | Q4 |
|---|---|---|
| Cardiac reserve during exercise by resting LVEDV quartile | ||
| Change in LV end-systolic volume | −4 mL | −12 mL |
| Change in LV stroke volume | +11 mL | +20 mL |
| Change in cardiac output | +6.6 L/min | +10.3 L/min |
- Cardiac reserve during exercise by resting LVEDV quartile: interaction P < 0.001 for all
Cardiac reserve during exercise by resting LVEDV quartile
- Increasing LVEDV quartiles positively associated with cardiac reserve
Original publication
Too Little of a Good Thing. JACC Cardiovasc Imaging. Published 8 February 2023. doi:10.1016/j.jcmg.2022.12.009
Summarised from the published abstract; every number is checked against it