Prevention & lipidsCohort study
Traditional risk factors, optimal cardiovascular health, and elevated lipoprotein(a)
- Prospective cohort study (secondary analysis of the Multi-Ethnic Study of Atherosclerosis)
Authors' conclusion
Participants without clinical ASCVD who achieved an optimal LS7 score had ASCVD risk reduction regardless of Lp(a) level.
Study context
- Population
- Participants without clinical atherosclerotic cardiovascular disease (ASCVD) from MESA who underwent Lp(a) testing
- Participants
- 6,676 participants
- Exposure
- Optimal vs poor LS7 score across Lp levels
- Outcome
- Incident ASCVD (CHD and stroke)
- Follow-up
- Median 17.7 years
Main finding
As reported in the abstract
Incident ASCVD, optimal vs poor LS7, by Lp(a) level
Optimal LS7 vs Poor LS7Hazard ratio (95% CI)
Lp(a) < 30 mg/dL
0.45(0.28–0.71)
Lp(a) 30-49 mg/dL
0.12(0.02–0.89)
Lp(a) ≥ 50 mg/dL
0.35(0.13–0.99)
- No significant interaction between Lp(a) and LS7 score on incident ASCVD
- P for interaction = 0.60
Observational data: associations, not effects.
Original publication
Traditional risk factors, optimal cardiovascular health, and elevated lipoprotein(a). Eur J Prev Cardiol. Published 28 November 2024. doi:10.1093/eurjpc/zwae382
Summarised from the published abstract; every number is checked against it