Heart failure & cardiomyopathiesResearch article
Trajectories of coronary sinus pacing cathode to predict cardiac resynchronization therapy outcome: The TRAJECTORIES study
- Multicentre study of a fluoroscopy imaging-based method (3DTraj) to predict cardiac resynchronization therapy (CRT) response
- 6 centers
Authors' conclusion
TRAJ-index seems to aid the intra-operative choice of CS-pacing site at CRT implant, with no additional tools.
Study context
- Population
- Patients undergoing CRT implants
- Participants
- 82 patients
- Comparison
- TRAJ-index compared with the volumetric response at echocardiography
Main finding
As reported in the abstract
Volumetric response (LV end-systolic volume decrease) · 8-month median follow-up (interquartile range 7-10)
Responders
50 (61%)
Further findings
| Outcome | Values |
|---|---|
| TRAJ-index prediction of response | TRAJ-index Positive response predicted 88% · Negative response predicted 66% · Overall accuracy 77% · Area under curve 0.86 |
TRAJ-index prediction by left ventricular (LV) volume and mitral regurgitation
- Less effective in large LV volumes and, not significantly, in major mitral regurgitations
Original publication
Trajectories of coronary sinus pacing cathode to predict cardiac resynchronization therapy outcome: The TRAJECTORIES study. Heart Rhythm. Published 15 April 2026. doi:10.1016/j.hrthm.2026.04.011
Summarised from the published abstract; every number is checked against it