Trajectories of Renal Biomarkers and New-Onset Heart Failure in the General Population: Findings from the PREVEND Study
Authors' conclusion
Our population-based study identified different but often stable longitudinal patterns of UAE and serum creatinine. Patients with persistently worse renal function, such as higher UAE or serum creatinine, were at a higher risk of HF or mortality.
Study context
- Population
- General population, PREVEND study
- Participants
- 6,881 participants
- Exposure
- Trajectories of urinary albumin excretion (UAE) and serum creatinine
- Outcome
- New-onset HF and all-cause mortality
- Follow-up
- 11-years of follow-up
Methodological detailsgroup-based trajectory analysis, population-based
- Group-based trajectory analysis
- Population-based
Main finding
As reported in the abstract
- Most participants had stable low UAE or serum creatinine
- Persistently high UAE: higher risk of new-onset heart failure (HF) or all-cause mortality
- Stable serum creatinine trajectories: linear association with new-onset HF, no association with all-cause mortality
Observational data: associations, not effects.
Further findings
Characteristics of persistently higher UAE or serum creatinine
- Older, more often men, more often comorbidities (DM, previous MI, dyslipidaemia)
Original publication
Trajectories of Renal Biomarkers and New-Onset Heart Failure in the General Population: Findings from the PREVEND Study. Eur J Heart Fail. Published 4 July 2023. doi:10.
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