Cohort study
Trajectories of Sleep Over Midlife and Incident Cardiovascular Disease Events in the Study of Women’s Health Across the Nation
- Prospective cohort study
- group-based trajectory modeling
Authors' conclusion
Insomnia symptoms, when persistent over midlife or occurring with short sleep, are associated with higher CVD risk among women.
Study context
- Population
- Midlife women (SWAN), aged 42–52, premenopausal or early perimenopausal, no hormone therapy, free of cardiovascular disease (CVD) at baseline; sleep assessed up to 16 times over 22 years
- Participants
- 1,142 / 564 / 590 / 668 / 363 / 1,394 / 760
- Exposure
- Midlife insomnia and sleep duration trajectories and incident CVD
- Low insomnian = 1,142reference
- Moderate decreasing insomnian = 564
- Low increasing insomnian = 590
- Persistently high insomnian = 668
- Persistently short sleepn = 363
- Moderate sleepn = 1,394reference
- Moderate to long sleepn = 760
- Outcome
- CVD events:
- Fatal or nonfatal MI
- Stroke
- HF
- Revascularization
Main finding
As reported in the abstract
CVD events
Hazard ratio (95% CI)P value
Persistently high insomnia vs Low insomnia
1.71(1.19–2.46)
P = 0.004Persistently short sleep vs Moderate sleep
1.51(0.98–2.33)
P = 0.06Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CVD events, persistent high insomnia plus short sleep · multivariable | 1.75 (1.03–2.98) | P = 0.04 | |
| 0.20.5125Hazard ratio (log scale) |
Insomnia and CVD, adjusted for vasomotor symptoms, snoring or depression
- Relations of insomnia to CVD persisted
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Trajectories of Sleep Over Midlife and Incident Cardiovascular Disease Events in the Study of Women’s Health Across the Nation. Circulation. Published 29 January 2024. doi:10.1161/circulationaha.123.066491
Summarised from the published abstract; every number is checked against it