Heart failure & cardiomyopathies
Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study
Authors' conclusion
While baseline hsCRP was not associated with incident HF, an increasing trajectory of hsCRP over time was associated with increased risk for incident HF (particularly HF with preserved ejection fraction).
Study context
- Population
- Black adults in the Jackson Heart Study (JHS), hsCRP measured over 3 visits 2000–2013; mean age 54±13 years, 63.8% women
- Participants
- 3,920 adults
- Exposure
- Baseline and trajectory of hsCRP vs incident heart failure (HF) hospitalization
- Outcome
- Incident HF hospitalization
- Follow-up
- Median 12 years
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Baseline hsCRPnot associated
1.08(0.96–1.22)
Increasing hsCRP levels over repeated measureshigher risk of incident HF overall
1.22(1.03–1.44)
Observational data: associations, not effects.
Further findings
Incident HFpEF
| Adjusted HR (95% CI) | ||
|---|---|---|
| Increasing hsCRP levels over repeated measuresHF with preserved ejection fraction | 1.30 (1.02–1.65) | |
| 0.512Adjusted hazard ratio (log scale) |
Incident HFrEF
- Increasing hsCRP levels not associated with HF with reduced ejection fraction
- P > 0.05
Change in hsCRP visit 1 to visit 3 (vs low-to-low)
- Changes in hsCRP from low-to-high and high-to-low levels associated with incident HF
- P < 0.05
Original publication
Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study. Circ Heart Fail. Published 9 August 2024. doi:10.
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