Valvular & structural heart disease
Transcatheter aortic valve implantation in severe aortic stenosis does not necessarily reverse left ventricular myocardial damage: data of long-term follow-up
Authors' conclusion
In a population of severe symptomatic AS patients who had undergone a TAVI, the non-invasive myocardial indices that assess the LV performance at long-term follow-up did not improve.
Study context
- Population
- Patients with severe symptomatic aortic stenosis (AS) with a validated indication for transcatheter aortic valve implantation (TAVI)
- Participants
- 102 patients
- Exposure
- Before vs after TAVI
- Outcome
- Echocardiographic LV function and myocardial work, before vs after TAVI
- Follow-up
- 22 ± 9.5 months after TAVI
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
22 ± 9.5 months after TAVI
- LVEF stable
- 62 ± 8%
- Global longitudinal strain improved
- −14.0 ± 3.7 vs. −16.0 ± 3.6%, P < 0.0001
- Left ventricular (LV) global work index, no improvement
- 2099 ± 692 vs. 2066 ± 706 mmHg%, P = 0.8
- LV global constructive work, no improvement
- 2463 ± 736 vs. 2463 ± 676 mmHg%, P = 0.8
- Global wasted work increased
- 214 (149; 357) vs. 247 (177; 394) mmHg%, P = 0.0008
Observational data: associations, not effects.
Safety
TAVI dysfunction · 22 ± 9.5 months after TAVI
- No TAVI dysfunction observed
Original publication
Transcatheter aortic valve implantation in severe aortic stenosis does not necessarily reverse left ventricular myocardial damage: data of long-term follow-up. Eur Heart J Cardiovasc Imaging. Published 17 January 2024. doi:10.
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