Valvular & structural heart disease
Transcatheter aortic valve replacement outcomes in patients with low-flow very low-gradient aortic stenosis
Main findingResult — go to the resultAdjusted hazard ratio 2.42 CI 1.29–4.55Authors' conclusion
Low-flow very LG severe AS represents a distinct population with significant comorbidities and worse outcomes.
Study context
- Population
- Patients with low-flow severe aortic stenosis (AS), 2019–2021
- Participants
- 662 patients
- Exposure
- Very low-gradient (LG) vs LG vs high-gradient (HG) low-flow severe AS
- Very LGn = 130
- LGn = 339
- HGn = 193
- Outcome
- Composite of:
- All-cause mortality
- HF rehospitalization
- Follow-up
- Median 12 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Adjusted hazard ratio
2.42
CI 1.29–4.55
Very LG
adjusted HR 2.42 (CI 1.29–4.55)
- Graded increase in risk of composite endpoint in lower mean pressure gradient (MPG) strata
- P < 0.001
Observational data: associations, not effects.
Further findings
LVEF
| Outcome | Adjusted HR (CI) | |
|---|---|---|
| Composite endpoint, TAVRvs conservative management, by gradientVery LG: no risk reduction | 0.69 (0.35–1.34) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- LVEF: P < 0.001
LVEF
- Very LG had higher prevalence of comorbid conditions
Composite endpoint, transcatheter aortic valve replacement (TAVR) vs conservative management, by gradient
- LG and HG had decreased risk of composite endpoint after TAVR vs conservative management
Original publication
Transcatheter aortic valve replacement outcomes in patients with low-flow very low-gradient aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 29 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →