Valvular & structural heart diseaseCohort study
Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation
- Registry study
- investigator-initiated
- multicenter
Authors' conclusion
M-TEER effectively reduces MR to ≤1+ and improves symptoms in both aSMR and vSMR. Particularly in aSMR, ≥moderate baseline TR is linked to worse outcomes
Study context
- Population
- Patients with secondary mitral regurgitation undergoing M-TEER (REPAIR registry)median follow-up 491 days
- Participants
- 915 patients
- Exposure
- aSMR vs vSMR undergoing M-TEER with PASCAL
- aSMRn = 166
- vSMRn = 749reference
- Outcome
- MR ≤1+ at discharge, technical success, NYHA class improvement, 1-year survival
Main finding
As reported in the abstract
MR ≤1+ at discharge, technical success, NYHA class improvement, 1-year survival (aSMR vs vSMR)
NYHA class improved in both phenotypes
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| 1-year survival by baseline TR, aSMR (subgroup) | TR ≥moderate 84.3% (95% CI 77.0%–92.3%) · TR <moderate 100.0% (95% CI 100.0%–100.0%) | P = 0.041 |
| 1-year survival by baseline TR, vSMR (subgroup) | TR ≥moderate 83.9% (95% CI 79.8%–88.2%) · TR <moderate 89.3% (95% CI 85.0%–93.8%) | P = 0.051 |
Original publication
Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation. JACC Cardiovasc Interv. Published 25 June 2025. doi:10.1016/j.jcin.2025.05.031
Summarised from the published abstract; every number is checked against it