Valvular & structural heart diseaseCohort study
Transcatheter edge-to-edge repair vs medical therapy in atrial functional mitral regurgitation: a propensity score-based comparison from the OCEAN-Mitral and REVEAL-AFMR registries
- Registry-based cohort study
- propensity score overlap weighting
Authors' conclusion
In real-world data, TEER for patients with moderate or severe AFMR were associated with a lower incidence of adverse events compared with medical treatment.
Study context
- Population
- Patients with moderate or severe atrial functional mitral regurgitation
- Participants
- 1,081 patients
- Exposure
- Transcatheter edge-to-edge repair (TEER) vs medical therapy
- TEERn = 441
- Medical treatmentn = 640reference
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
Main finding
As reported in the abstract
Hazard ratio
0.65
95% CI 0.43–0.99
P = 0.044
TEER vs Medication
HR 0.65 (95% CI 0.43–0.99); P = 0.044
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · overlap weighting | 0.58 (0.35–0.99) | P = 0.044 | |
| 0.20.5125Hazard ratio (log scale) |
Exploratory subgroup by residual atrial functional mitral regurgitation (AFMR) after TEER
- Favourable outcomes might be pronounced with ≤mild residual AFMR; event rates with ≥ moderate residual AFMR comparable with medication
Sensitivity analyses (IPTW, propensity score matching, multivariable Cox regression)
- All confirmed favourable associations of TEER with both endpoints
- IPTW n = 158 vs 173; matching n = 104 vs 104; Cox n = 441 vs. 640
Original publication
Transcatheter edge-to-edge repair vs medical therapy in atrial functional mitral regurgitation: a propensity score-based comparison from the OCEAN-Mitral and REVEAL-AFMR registries. Eur Heart J. Published 1 August 2025. doi:10.1093/eurheartj/ehaf511
Summarised from the published abstract; every number is checked against it