Valvular & structural heart diseaseMeta-analysis
Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk
- Individual participant data and aggregate meta-analysis of randomised trials
- 1-stage and 2-stage individual participant data (IPD) meta-analyses
Authors' conclusion
In this IPD meta-analysis of 4 RCTs, and an overall meta-analysis of 8 RCTs of patients with severe symptomatic AS at low to intermediate risk, TAVI was associated with a reduction in the 1-year incidence of all-cause death or any stroke.
Study context
- Population
- Severe symptomatic AS at low to intermediate surgical risk4 randomized clinical trials (RCTs) (IPD)
- Participants
- 2,873 participants
- Comparison
- Transcatheter aortic valve implantation (TAVI) vs surgical aortic valve replacement (SAVR)
- TAVIn = 1,439
- SAVRn = 1,434reference
- Outcome
- All-cause death or any stroke
- Follow-up
- 1 year after randomization
Pooled result
As reported in the abstract
1 year
TAVI vs SAVRHazard ratio (95% CI)
1-stage IPD meta-analysis
0.73(0.56–0.95)
2-stage IPD meta-analysis
0.79(0.49–1.27)
2-stage overall meta-analysis (8 RCTs)
0.76(0.60–0.97)
Original publication
Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk. JAMA Cardiol. Published 1 November 2025. doi:10.1001/jamacardio.2025.3403
Summarised from the published abstract; every number is checked against it