Valvular & structural heart diseaseResearch article
Transcatheter Repair in Posterior, Anterior, and Bileaflet Mitral Valve Disease
- Pooled patient-level analysis of the EXPAND and EXPAND G4 studies
Authors' conclusion
Results from the EXPANDed studies demonstrate that subjects with DMR treated with M-TEER experienced significant improvements in outcomes, regardless of the location of prolapse or flail.
Study context
- Population
- Patients with degenerative mitral regurgitation (MR) undergoing mitral transcatheter edge-to-edge repair (M-TEER) with the MitraClip G3 or G4 systemof 2,205 in EXPANDed
- Participants
- 556 patients
- Comparison
- Posterior vs anterior vs bileaflet degenerative mitral regurgitation (DMR) treated with M-TEER
- Posteriorn = 389reference
- Anteriorn = 106
- Bileafletn = 61
Main finding
As reported in the abstract
30-day major adverse events · 30 days
Further findings
MR ≤1+ · 1 year
- MR ≤1+: denominators 219, 57, 29
MR ≤1+ · 1 year
- All groups showed a significant reduction in MR severity from baseline
Procedural outcomes
- Low device and procedure times with high procedural success (discharge MR ≤2+) in all groups
Original publication
Transcatheter Repair in Posterior, Anterior, and Bileaflet Mitral Valve Disease. JACC Cardiovasc Interv. Published 5 March 2025. doi:10.1016/j.jcin.2024.12.023
Summarised from the published abstract; every number is checked against it