Cardio-oncology & otherCase-control study
Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study
- Case-control study
- matched
Authors' conclusion
Using high-dimensional data selection methods has enabled the identification of the gene NFE2L2, associated with CD and HF in CCS.
Study context
- Population
- Childhood cancer survivors
- Participants
- 330 survivors
- Comparison
- CD cases vs CD-free controls
- Casesn = 165
- Controlsn = 165reference
- Outcome
- Transcriptomic biomarkers (expression of 8557 genes) associated with CD and HF
Main finding
As reported in the abstract
NFE2L2 expression (sole gene in final selection), lower in cases than controls
OR
- CD
- .16 (95% CI .09-.29)
- Heart failure (HF)
- .11 (95% CI .03-.37)
Observational data: associations, not effects.
Further findings
Interaction between treatment doses and NFE2L2 expression
- No interaction found
Discrimination of prognostic models with NFE2L2 vs clinical and treatment variables only
- CD: AUC with NFE2L2 vs without
- .85 vs .66
- HF: AUC with NFE2L2 vs without
- .87 vs .77
Original publication
Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study. Eur Heart J. Published 23 September 2025. doi:10.1093/eurheartj/ehaf617
Summarised from the published abstract; every number is checked against it