Valvular & structural heart disease
Transthyretin Amyloid Cardiomyopathy in Aortic Stenosis Patients Scheduled for Transcatheter Aortic Valve Implantation
Authors' conclusion
We found concomitant AS and ATTR-CM in 5% of our TAVI patients. Carpal tunnel syndrome and LFLG AS suggest concomitant ATTR.
Study context
- Population
- Patients accepted for TAVI for severe aortic stenosis (AS)consecutive patients aged 79 ± 7 years, 57% were male
- Participants
- 171 patients
- Outcome
- Cardiac bone tracer uptake ≥ Perugini Grade 2 and no abnormal monoclonal protein/free light chains
Methodological detailsbone scintigraphy screening, bioptic verification of Grade 1 or ambiguous DPD uptake
- Bone scintigraphy screening
- Bioptic verification of Grade 1 or ambiguous DPD uptake
Main finding
As reported in the abstract
Patients
Six patients (3.5%)
Further findings
ATTR-CM confirmed by endomyocardial biopsy
- Additional patients confirmed
- two additional patients (1.2%)
- Patients with low-grade uptake without ATTR-CM
- five patients
Concomitant AS and ATTR-CM
- Total diagnosed
- 8/171 patients (4.7%)
Characteristics of patients with concomitant ATTR-CM
- History of carpal tunnel syndrome
- 25%
- Most had low-flow low-gradient (LFLG) AS
Original publication
Transthyretin Amyloid Cardiomyopathy in Aortic Stenosis Patients Scheduled for Transcatheter Aortic Valve Implantation. ESC Heart Fail. Published 11 March 2025. doi:10.
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