Heart failure & cardiomyopathies
Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure
Authors' conclusion
In this cross-sectional study, ATTR-CA was an important cause of HF in older Black individuals with HF, particularly in men older than 75 years. Approximately half of V142I carriers with HF had ATTR-CA, while 55.8% of all ATTR-CA cases had normal TTR genotype.
Study context
- Population
- Self-identified Black or Caribbean Hispanic individuals older than 60 years with heart failure (HF), several major US cities
- Participants
- 646 participants
- Outcome
- Prevalence of ATTR-CA (radionuclide imaging) and proportions attributable to ATTRwt-CA or ATTRv-CA
Methodological detailsprospective, multicenter, Enrolled May 2019 to June 2024
- Prospective
- Multicenter
- Enrolled May 2019 to June 2024
Main finding
As reported in the abstract
Overall prevalence of ATTR-CA
6.66%
95% CI 4.73%–8.58%
ATTRwt-CA among ATTR-CA cases
24
55.8%
ATTRv-CA owing to V142I among ATTR-CA cases
19
44.2%
Observational data: associations, not effects.
Further findings
Men vs Women
| Outcome | Men | Women | P value |
|---|---|---|---|
| Prevalence of ATTR-CA by sex (subgroup) | 8.15% (95% CI 5.15%–11.15%) | 5.20% (95% CI 2.79%–7.61%) | P = 0.13 |
Black vs Hispanic
| Outcome | Black | Hispanic | P value |
|---|---|---|---|
| Prevalence of ATTR-CA by ethnicity (subgroup) | 7.82% (95% CI 5.57%–10.06%) | 2.15% (95% CI 0.07%–4.24%) | P = 0.004 |
Aged ≤75 years vs Older than 75 years
| Outcome | Aged ≤75 years | Older than 75 years | P value |
|---|---|---|---|
| Prevalence of ATTR-CA in Black participants by age (subgroup) | 3.42% (95% CI 1.43%–5.40%) | 14.04% (95% CI 9.53%–18.54%) | P < 0.001 |
V142I allele
- Overall prevalence of V142I allele
- 5.6%
- V142I carriers with ATTRv-CA
- 19 (52.8%)
Prevalence of ATTR-CA in Black men older than 75 years (subgroup)
- Prevalence
- 17.17% (95% CI 9.74%-24.60%)
Original publication
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