Heart failure & cardiomyopathiesCross-sectional study
Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure
- Cross-sectional study
- prospective
- multicenter
- Enrolled May 2019 to June 2024
Authors' conclusion
In this cross-sectional study, ATTR-CA was an important cause of HF in older Black individuals with HF, particularly in men older than 75 years. Approximately half of V142I carriers with HF had ATTR-CA, while 55.8% of all ATTR-CA cases had normal TTR genotype.
Study context
- Population
- Self-identified Black or Caribbean Hispanic individuals older than 60 years with heart failure (HF), several major US cities
- Participants
- 646 participants
- Outcome
- Prevalence of ATTR-CA (radionuclide imaging) and proportions attributable to ATTRwt-CA or ATTRv-CA
Main finding
As reported in the abstract
Overall prevalence of ATTR-CA
Overall prevalence of ATTR-CA
6.66% (95% CI 4.73%-8.58%)
ATTRwt-CA among ATTR-CA cases
24 (55.8%)
ATTRv-CA owing to V142I among ATTR-CA cases
19 (44.2%)
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Prevalence of ATTR-CA by sex (subgroup) | Men 8.15% (95% CI 5.15%–11.15%) · Women 5.20% (95% CI 2.79%–7.61%) | P = 0.13 |
| Prevalence of ATTR-CA by ethnicity (subgroup) | Black 7.82% (95% CI 5.57%–10.06%) · Hispanic 2.15% (95% CI 0.07%–4.24%) | P = 0.004 |
| Prevalence of ATTR-CA in Black participants by age (subgroup) | Aged ≤75 years 3.42% (95% CI 1.43%–5.40%) · Older than 75 years 14.04% (95% CI 9.53%–18.54%) | P < 0.001 |
V142I allele
- Overall prevalence of V142I allele
- 5.6%
- V142I carriers with ATTRv-CA
- 19 (52.8%)
Prevalence of ATTR-CA in Black men older than 75 years (subgroup)
- Prevalence
- 17.17% (95% CI 9.74%-24.60%)
Original publication
Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. JAMA Cardiol. Published 1 October 2025. doi:10.1001/jamacardio.2025.2948
Summarised from the published abstract; every number is checked against it