Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial
Primary resultResult — go to the resultAbsolute difference −0.6 percentage points 1-sided 97.5% CI upper boundary 1.1Authors' conclusion
Among patients with coronary artery disease, a treat-to-target LDL-C strategy of 50 to 70 mg/dL as the goal was noninferior to a high-intensity statin therapy for the 3-year composite of death, myocardial infarction, stroke, or coronary revascularization.
Study context
- Population
- Patients with CAD, South Korea, enrolled 2016–20194,341 (98.7%) completed
- Participants
- 4,400 patients
- Comparison
- Treat-to-target low-density lipoprotein cholesterol (LDL-C) strategy vs high-intensity statin
- Treat-to-targetn = 2,200
- High-intensity statinn = 2,200reference
- Primary endpoint
- Composite of:
- Death
- MI
- Stroke
- Coronary revascularization
- Follow-up
- 3 years
Methodological detailsmulticentre, non-inferiority, 12 centres in South Korea
- Multicentre
- Non-inferiority
- 12 centres in South Korea
Primary result
As reported in the abstract
Absolute difference
−0.6 percentage points
1-sided 97.5% CI upper boundary 1.1
P < 0.001 for noninferiority
Events by treatment group
Treat-to-targetvs High-intensity statin
absolute difference −0.6 percentage points (1-sided 97.5% CI upper boundary 1.1); P < 0.001 for noninferiority
Further findings
Mean LDL-C over 3 years
P = 0.21
- Statin dosing in treat-to-target
- 43% · Moderate-intensity dosing · High-intensity dosing 54%
Original publication
Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial. JAMA. Published 4 April 2023. doi:10.
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