Heart failure & cardiomyopathies
Treatment Patterns and Trajectories in Patients After Acute Heart Failure Hospitalization
Authors' conclusion
A substantial number of patients with HF experienced transitions to other categories after discharge. Notably, patients with decreased EF experienced a worse prognosis, even with slight decreases (e.g. HFpEF transitioning to HFmrEF).
Study context
- Population
- Patients hospitalised for acute heart failure (HF) with left ventricular ejection fraction (LVEF) data at admission and 1 year after discharge
- Participants
- 1,636 patients
- Exposure
- LVEF trajectory categories 1 year after discharge
- HFunc-pEFn = 527
- HFunc-mrEFn = 86
- HFunc-rEFn = 377reference
- HFworEFn = 83
- HFimpEFn = 563
- Outcome
- Composite of:
- CV death
- HF readmission
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
CV death and HF readmission
Each group vs HFunc-rEFHazard ratio (95% CI)P value
HFimpEF
0.28(0.16–0.49)
P < 0.001HFunc-pEF
0.40(0.25–0.63)
P < 0.001HFunc-mrEF
0.44(0.18–1.07)
P = 0.07HFworEF
0.63(0.29–1.39)
P = 0.26Observational data: associations, not effects.
Further findings
Transition of HF category during 1 year after discharge
- HFrEF transitioned to other categories
- 53%
- HF with mildly reduced EF (HFmrEF) transitioned to other categories
- 67%
- HF with preserved EF (HFpEF) remained within same category
- 92%
Original publication
Treatment Patterns and Trajectories in Patients After Acute Heart Failure Hospitalization. ESC Heart Fail. Published 14 December 2023. doi:10.
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