Heart failure & cardiomyopathies
Trends and Outcomes Associated With Bariatric Surgery and Pharmacotherapies With Weight Loss Effects Among Patients With Heart Failure and Obesity
Authors' conclusion
Bariatric surgery and pharmacotherapies with weight loss effects are associated with a lower risk of adverse outcomes among older patients with HF and obesity; however, overall utilization remains low.
Study context
- Population
- Medicare beneficiaries with heart failure (HF) and at least class II obesity, 2013–20202,594 (0.9%) had bariatric surgery
- Participants
- 298,101 beneficiaries
- Exposure
- Bariatric surgery or weight-loss pharmacotherapy vs matched controls
- Bariatric surgeryn = 2,594
- Outcome
- All-cause mortality and HF hospitalization rate (per 100 person-months)
Methodological detailspropensity-score matched, 1:2 matching
- Propensity-score matched
- 1:2 matching
Main finding
As reported in the abstract
Bariatric surgery vs matched controls · median follow-up 4.7 years
Bariatric surgery vs ControlsEstimate (95% CI)P value
All-cause mortality
HR 0.55(0.49–0.63)
P < 0.001HF hospitalization rate
rate ratio 0.72(0.67–0.77)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Weight-loss pharmacotherapy | Estimate | P value | |
|---|---|---|---|---|
| AF risk, bariatric surgery · median follow-up 4.7 yearsBariatric surgeryvs Controls | HR 0.78 (95% CI 0.65–0.93) | P = 0.006 | ||
| Weight-loss pharmacotherapyvs matched controls (exploratory) · median follow-up 2.8 yearsAll-cause mortality · exploratory analysis · propensity-matched · value = use rate | 4.8% | HR 0.82 (95% CI 0.71–0.95) | P = 0.007 | |
| GLP-1 agonists | 96.3% | |||
| Semaglutide | 23.6% | |||
| Liraglutide | 72.7% | |||
| Weight-loss pharmacotherapyvs matched controls (exploratory) · median follow-up 2.8 yearsHF hospitalization rate · exploratory analysis · propensity-matched · value = use rate | rate ratio 0.87 (95% CI 0.77–0.99) | P = 0.04 | ||
| 0.512Ratio (log scale) |
Original publication
Trends and Outcomes Associated With Bariatric Surgery and Pharmacotherapies With Weight Loss Effects Among Patients With Heart Failure and Obesity. Circ Heart Fail. Published 26 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →