Prevention & lipidsCohort study
Trends in atherosclerotic cardiovascular disease and lipid management: a population-level observational cohort study in Wales
- Retrospective observational population study
- linked healthcare data
- population-level
Authors' conclusion
Prescription of LLT, including high-intensity statin therapy, documentation of LDL-C, and achievement of target LDL-C levels was relatively low, especially in PAD patients. Although target achievement in 'tested patients' increased over time, the proportion of patients undergoing lipid testing declined.
Study context
- Population
- Patients with atherosclerotic CVD (ischaemic heart disease, stroke, peripheral arterial disease (PAD)) in Wales, 2010–22181,153 (2010) to 207,747 (2022)
- Outcome
- Trends in atherosclerotic CVD, including lipid lowering treatment, monitoring and achievement of target LDL-C
- Follow-up
- 2010–22
Main finding
As reported in the abstract
2010 to 2022
- Patients with atherosclerotic CVD (per 100 000), 2010 to 2022
- 8882 to 9398
- Prescribed lipid lowering treatment, 2010 to 2022
- 75.3% to 67.1%
- High-intensity statin, 2010 to 2022
- 9.4 to 25.2%
- Non-high-intensity statin, 2010 to 2022
- 59.6 to 38.2%
- Documented low-density lipoprotein cholesterol (LDL-C), 2010 to 2022
- 58.0% to 49.3%
- LDL-C < 1.8 mmol/L achieved, 2022 (of those with documented LDL-C)
- 44.0%
Observational data: associations, not effects.
Further findings
High-intensity statin prescription, by diagnosis (subgroup) · 2010 to 2022
- Ischaemic heart disease
- 10.9% to 28.0%
- Stroke
- 4.7-21.6%
- PAD
- 3.9-10.6%
LDL-C < 1.8 mmol/L achieved in 2022, by diagnosis (subgroup)
- Ischaemic heart disease
- 45.2%
- Stroke
- 42.0%
- PAD
- 32.8%
- of those with documented LDL-C
Original publication
Trends in atherosclerotic cardiovascular disease and lipid management: a population-level observational cohort study in Wales. Eur J Prev Cardiol. Published 23 July 2024. doi:10.1093/eurjpc/zwae233
Summarised from the published abstract; every number is checked against it