Acute cardiac care & resuscitationCohort study
Trends in the incidence and outcomes of cardiopulmonary resuscitation-induced consciousness in out-of-hospital cardiac arrest: a retrospective study
- retrospective cohort study
Authors' conclusion
Over the 16-year study period, the annual incidence of CPRIC increased, and patients with CPRIC found to have better OHCA survival outcomes. CPRIC may help identify patients with favourable physiology and is associated with improved survival outcomes.
Study context
- Population
- Adult (≥16 years) OHCA events between 1st January 2008 and 31st December 2024, linked to the Victorian Ambulance Cardiac Arrest Registry (VACAR)OHCA events, 1438 patients (3.3%) experienced cardiopulmonary resuscitation induced consciousness (CPRIC)
- Participants
- 43,402 participants
- Exposure
- CPRIC and survival to hospital discharge
- CPRICn = 1,438
Main finding
As reported in the abstract
Annual incidence of CPRIC (temporal trend)
IRR, overall cohort
1.083 (95% CI 1.07-1.10)
Increase across all arrest rhythms
p < 0.001 for all
Observational data: associations, not effects.
Further findings
Factors independently associated with CPRIC
- younger age, calendar year, cardiac aetiology, public location, witnessed arrest, initial shockable rhythm and use of mechanical CPR
Survival to hospital discharge
- CPRIC, OR
- 2.71 (95% CI 2.38-3.09)
- interfering phenotype, OR
- 2.36 (95% CI 2.04-2.74)
- non-interfering phenotype, OR
- 4.09 (95% CI 3.17-5.29)
- adjusted analysis
- multivariable logistic regression
Return of spontaneous circulation and survival to hospital admission
- CPRIC was also associated with return of spontaneous circulation and survival to hospital admission
Original publication
Trends in the incidence and outcomes of cardiopulmonary resuscitation-induced consciousness in out-of-hospital cardiac arrest: a retrospective study. Resuscitation. Published 4 September 2026. doi:10.1016/j.resuscitation.2026.111287
Summarised from the published abstract; every number is checked against it