Valvular & structural heart diseaseCohort study
TRI-SCORE and benefit of intervention in patients with severe tricuspid regurgitation
- Registry-based observational cohort study
Authors' conclusion
Survival progressively decreased with the TRI-SCORE irrespective of treatment modality. Compared to conservative management, an early and successful surgical or transcatheter intervention improved 2-year survival in patients at low and, to a lower extent, intermediate TRI-SCORE, while no benefit was observed in the high TRI-SCORE category.
Study context
- Population
- Patients with severe isolated functional tricuspid regurgitation (TR) (TRIGISTRY)
- Participants
- 2,413 patients
- Exposure
- Surgical or transcatheter intervention vs conservative management, by TRI-SCORE category
- Conservative managementn = 1,217reference
- Surgicaln = 551
- Transcathetern = 645
- Outcome
- Survival
- Follow-up
- 2 years
Main finding
As reported in the abstract
Low TRI-SCORE (≤3): Surgical vs Transcatheter vs Conservative management
93%, 87%, and 79%, P = .0002
Intermediate TRI-SCORE (4-5): Surgical vs Transcatheter vs Conservative management, no significant difference
80%, 71%, and 71%, P = .13
High TRI-SCORE (≥6): Surgical and successful repair vs Conservative management, not different
61% and 68% vs 58%, P = .26 and P = .18
Survival decreased with TRI-SCORE in all three treatment groups
all P < .0001
Observational data: associations, not effects.
Further findings
| Outcome | Conservative management | Surgical | Transcatheter |
|---|---|---|---|
| Successful TR correction | Not reported in the abstract | 97% | 65% |
2-year survival, intermediate TRI-SCORE, successful correction only (subgroup)
- Surgical vs Transcatheter vs Conservative management
- 80%, 81%, and 71%, P = .009
TRI-SCORE distribution
- Low (≤3)
- 32%
- Intermediate (4-5)
- 33%
- High (≥6)
- 35%
Original publication
Summarised from the published abstract; every number is checked against it