Heart failure & cardiomyopathiesCohort study
Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction
- Cohort study
Authors' conclusion
STR in HFpEF is associated with PVD and less strongly with higher resting filling pressure.
Study context
- Population
- Patients evaluated with hemodynamics (rest and leg-elevation or exercise), including heart failure with preserved ejection fraction (HFpEF) phenotypes and noncardiac dyspnea669 (61.3%) with HFpEF
- Participants
- 1,091 patients
- Exposure
- HFpEF phenotypes by pulmonary vascular disease (PVD) and rest vs provoked filling pressure elevation; atrial vs ventricular secondary tricuspid regurgitation (STR)
- Outcome
- Prevalence, distribution and prognostic significance of STR mechanisms across HFpEF
Main finding
As reported in the abstract
Moderate or severe STR
- Moderate or severe STR overall
- 17.4%
- Exercise-only HFpEF vs noncardiac dyspnea: moderate or severe STR 11.7% vs 6.5%
- P = 0.047
- STR fulfilling criteria for V-STR
- 69%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Death or HF hospitalization (composite) · also associated with death and HF hospitalization each alone | multivariable HR 1.70 (95% CI 1.10–2.65) | |
| HF hospitalization | multivariable Fine-Gray HR 2.21 (95% CI 1.12–4.37) | |
| 0.20.5125Ratio (log scale) |
AF and atrial remodeling, V-STR vs A-STR
- V-STR had similar AF prevalence and greater atrial remodeling vs A-STR
Original publication
Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. Published 29 October 2025. doi:10.1016/j.jacc.2025.09.007
Summarised from the published abstract; every number is checked against it