Valvular & structural heart diseaseCohort study
Tricuspid regurgitation and outcomes in mitral valve transcatheter edge-to-edge repair
- Registry-based cohort study
Authors' conclusion
Post-procedural TR, but not baseline TR, was associated with outcomes after M-TEER.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) in the OCEAN-Mitral registry; significant tricuspid regurgitation (TR) = TR ≥ moderate
- Participants
- 2,103 / 201 / 504 / 858
- Exposure
- TR status before/after M-TEER: new-onset, residual or normalized TR vs no TR
- no TRn = 2,103reference
- new-onset TRn = 201
- normalized TRn = 504
- residual TRn = 858
- Outcome
- CV death or HF hospitalization
Main finding
As reported in the abstract
CV death or HF hospitalization (adjusted)
Each group vs no TRHazard ratio (95% CI)
new-onset TR
1.83(1.39–2.40)
residual TR
1.45(1.23–1.72)
normalized TR
0.82(0.65–1.04)
Observational data: associations, not effects.
Further findings
Baseline TR and TR pressure gradient
- Baseline TR and TR pressure gradient not associated with outcomes after M-TEER
Change in TR pressure gradient from baseline to post-procedure
- TR pressure gradient changes associated with subsequent outcomes after M-TEER
Factors associated with new-onset and residual TR
- Commonly associated with dilated tricuspid annulus diameter and AF
Original publication
Tricuspid regurgitation and outcomes in mitral valve transcatheter edge-to-edge repair. Eur Heart J. Published 28 January 2025. doi:10.1093/eurheartj/ehae924
Summarised from the published abstract; every number is checked against it