Heart failure & cardiomyopathies
Triglyceride Glucose Index is a Risk Factor for Heart Failure: A Prospective Cohort Study
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.6 95% CI 1.22–2.09Authors' conclusion
The TyG index was positively associated with increased all-cause mortality in hospitalized patients with HF. Subgroup analyses indicated that the TyG index was strongly associated with all-cause mortality in older and female patients.
Study context
- Population
- Patients with heart failure (HF) diagnosed at Hebei General Hospital
- Participants
- 1,274 patients
- Exposure
- Triglyceride glucose (TyG) index quartiles
- Outcome
- All-cause mortality
- Follow-up
- Median 1079 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
1.6
95% CI 1.22–2.09
P = 0.001
Q4vs Q1
HR 1.6 (95% CI 1.22–2.09); P = 0.001
- Total deaths
- 543 (42.7%)
- Unadjusted survival curves: no significant difference among the four groups
- log-rank P = 0.329
- Adjusted survival curves (Model 3): higher TyG index, higher risk of death
- log-rank P < 0.001
- Risk increased linearly with TyG index (restricted cubic spline)
- P for non-linear = 0.207
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality per TyG index (continuous), female patients (exploratory subgroup) | 1.31 (1.08–1.58) | P = 0.029 | |
| All-cause mortality per TyG index (continuous), older patients (exploratory subgroup) | 1.25 (1.1–1.43) | P = 0.027 | |
| 0.512Hazard ratio (log scale) |
Original publication
Triglyceride Glucose Index is a Risk Factor for Heart Failure: A Prospective Cohort Study. ESC Heart Fail. Published 17 July 2024. doi:10.
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