Prevention & lipidsSecondary analysis
Triglyceride-glucose index, low-density lipoprotein levels, and cardiovascular outcomes in chronic stable cardiovascular disease: results from the ONTARGET and TRANSCEND trials
- Secondary analysis of the ONTARGET and TRANSCEND randomised trials
Authors' conclusion
A higher TyG index is associated with a modestly increased cardiovascular risk in chronic stable cardiovascular disease. This association is largely attenuated when LDL levels are controlled.
Study context
- Population
- Patients with known atherosclerotic disease (chronic stable CVD) in the ONTARGET and TRANSCEND trials
- Participants
- 29,960 patients
- Comparison
- Highest vs lowest quartile of the TyG index
- Primary endpoint
- Composite of:
- CV death
- MI
- Stroke
- Hospitalization for HF
- Follow-up
- Mean 4.3 years
Primary result
Primary endpoint
Hazard ratio
1.14
95% CI 1.05–1.25
Highest quartile vs Lowest quartile
HR 1.14 (95% CI 1.05–1.25)
As reported in the abstract
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| MI · fully adjusted | 1.30 (1.11–1.53) | |
| 0.512Hazard ratio (log scale) |
Primary endpoint, low density lipoprotein (LDL) < 100 mg/dL (subgroup)
- Higher TyG index not associated with the primary endpoint
Original publication
Triglyceride-glucose index, low-density lipoprotein levels, and cardiovascular outcomes in chronic stable cardiovascular disease: results from the ONTARGET and TRANSCEND trials. Eur J Prev Cardiol. Published 27 October 2023. doi:10.1093/eurjpc/zwad340
Summarised from the published abstract; every number is checked against it