Heart failure & cardiomyopathies
Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure
Primary result · Survival at 2 years free of disabling stroke (modified Rankin score >3) or reoperation to replace or remove a malfunctioning deviceResult — go to the resultAbsolute difference 19.2 percentage pointsAuthors' conclusion
In patients with advanced heart failure, a fully magnetically levitated centrifugal-flow pump was superior to a mechanical-bearing axial-flow pump with regard to survival free of disabling stroke or reoperation to replace or remove a malfunctioning device.
Study context
- Population
- Patients with advanced HF, irrespective of intended goal of support (bridge to transplantation or destination therapy)
- Participants
- 366 patients
- Comparison
- Magnetically levitated centrifugal-flow pump vs mechanical-bearing axial-flow pump
- Centrifugal-flow pumpn = 190
- Axial-flow pumpn = 176reference
- Primary endpoint
- Survival free of disabling stroke (modified Rankin score >3) or reoperation to replace or remove a malfunctioning device
- Follow-up
- 2 years
Methodological detailsnon-inferiority and superiority
- Non-inferiority and superiority
Primary result
As reported in the abstract
Survival at 2 years free of disabling stroke (modified Rankin score >3) or reoperation to replace or remove a malfunctioning device
Absolute difference
19.2 percentage points
P < 0.001 for noninferiority
Events by treatment group
Further findings
Death and disabling stroke
- Rates similar in the two groups
Safety
| Outcome | Centrifugal-flow pump | Axial-flow pump | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Reoperation for pump malfunction | 1.6% | 17.0% | 0.08 (0.03–0.27) | P < 0.001 | |
| Overall stroke | 10.1% | 19.2% | 0.47 (0.27–0.84) | P = 0.02 | |
| 0.050.21520Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. N Engl J Med. Published 11 March 2018. doi:10.
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