Heart failure & cardiomyopathies
U-Shaped Association Between Body Mass Index and Ejection Fraction in Intensive Care Unit Patients with Heart Failure
Authors' conclusion
In addition to higher BMI, we also found that lower BMI is related to higher EF in intensive care unit patients with HF, supporting a U-shaped association between BMI and EF.
Study context
- Population
- ICU patients with heart failure (HF)
- Participants
- 962 patients
- Exposure
- Body mass index (BMI) <23.3 vs ≥23.3 kg/m²
- Outcome
- Association between BMI and LVEF
Methodological detailsMIMIC-III database (Dryad Digital Repository), smooth curve and two piecewise linear regression
- MIMIC-III database (Dryad Digital Repository)
- Smooth curve and two piecewise linear regression
Main finding
As reported in the abstract
EF per BMI unit (adjusted β)
β
−0.7
95% CI −1.3 to −0.1P = 0.028
BMI < 23.3 kg/m² · ejection fraction (EF) decreased with increasing BMI up to inflection point
β
0.2
95% CI 0.1–0.3P < 0.001
BMI ≥ 23.3 kg/m² · positive correlation beyond turning point
- U-shaped relationship between BMI and EF; inflection point BMI
- 23.3 kg/m²
Observational data: associations, not effects.
Further findings
Effect modifiers of BMI–EF association (subgroup)
- Ischaemic heart disease, lower BMI group
- interaction P = 0.0499
- Hyperlipidaemia, lower BMI group
- interaction P = 0.0162
- DM, higher BMI group
- interaction P = 0.0255
Original publication
U-Shaped Association Between Body Mass Index and Ejection Fraction in Intensive Care Unit Patients with Heart Failure. ESC Heart Fail. Published 17 October 2022. doi:10.
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