Heart failure & cardiomyopathiesCohort study
Understanding the incidence of atrial fibrillation and stroke in hypertrophic cardiomyopathy patients: insights from Danish nationwide registries
- Retrospective cohort study
- nationwide registries
Authors' conclusion
Obstructive HCM, HT, and IHD were associated with increased risk of AF. Prevalent AF alone was not predictive of stroke; however, AF patients treated with OAC were significantly less likely to develop stroke, suggesting that this development is driven by the protective effect of OAC.
Study context
- Population
- Hypertrophic cardiomyopathy (HCM) patients without prevalent atrial fibrillation (AF), Danish national registries, 2005–2018without prevalent AF
- Participants
- 3,367 patients
- Outcome
- Incidence of AF and stroke and their risk factors
- Follow-up
- Median 4 years
Main finding
As reported in the abstract
Incident AF
Hazard ratio (95% CI)
IHD
1.33(1.08–1.63)
HT
1.36(1.14–1.67)
Obstructive HCM
1.27(1.05–1.52)
- Incident AF (death as competing risk)
- 24%
- Stroke
- Seven per cent
Observational data: associations, not effects.
Further findings
Stroke in AF treated with OAC (sub-analysis)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| OAC | 0.4 (0.18–0.86) | P = 0.02 | |
| 0.20.5125Hazard ratio (log scale) |
Inadequate anticoagulation after AF diagnosis
- Not receiving adequate anticoagulation
- 34%
Original publication
Understanding the incidence of atrial fibrillation and stroke in hypertrophic cardiomyopathy patients: insights from Danish nationwide registries. Europace. Published 25 June 2024. doi:10.1093/europace/euae177
Summarised from the published abstract; every number is checked against it