Valvular & structural heart diseaseCohort study
UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves
- Multicentre registry study
- 9 sites
- consecutive patients
Authors' conclusion
UNICORN during TAVR was successful in preventing coronary obstruction. Intraprocedural hypotension requiring vasopressor support was frequent.
Study context
- Population
- Patients undergoing UNICORN transcatheter aortic valve replacement (TAVR) in native, surgical or transcatheter aortic valves, March 2024 to May 20258 native, 30 surgical, 15 TAVR valves
- Participants
- 53 patients
- Outcome
- Primary success: UNICORN TAVR without periprocedural coronary obstruction, reintervention or death
Main finding
As reported in the abstract
Primary success (UNICORN TAVR without periprocedural coronary obstruction, reintervention or death)
Primary success
51 patients (96%)
Observational data: associations, not effects.
Further findings
Coronary obstruction requiring rescue PCI
- Coronary obstruction with rescue PCI
- 2 (4%)
Safety
Overall 30-day safety
- Overall 30-day safety
- 46 patients (87%)
- Stroke
- 3 (6%)
- Life-threatening bleeding
- 2 (4%)
- Major vascular complications
- 2 (4%)
- Deaths, valve-related reinterventions, stage 3–4 AKI
- 0
Intraprocedural hypotension
- Intraprocedural hypotension
- 12 (23%)
Original publication
UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves. JACC Cardiovasc Interv. Published 22 June 2026. doi:10.1016/j.jcin.2026.04.030
Summarised from the published abstract; every number is checked against it