Prevention & lipidsCohort study
Unidirectional association of clonal hematopoiesis with atherosclerosis development
- Prospective cohort study
- longitudinal
High-sensitivity DNA sequencing in blood and noninvasive vascular imaging
Authors' conclusion
These findings indicate that clonal hematopoiesis unidirectionally promotes atherosclerosis
Study context
- Population
- Healthy middle-aged individuals
- Exposure
- CH-related mutation vs none; atherosclerosis vs none
Main finding
As reported in the abstract
Interplay between clonal hematopoiesis and atherosclerosis · 6-year period
- CH-related mutation confers increased risk of de novo femoral atherosclerosis
- Neither presence nor extent of atherosclerosis affects mutant cell expansion
Observational data: associations, not effects.
Original publication
Unidirectional association of clonal hematopoiesis with atherosclerosis development. Nat Med. Published 30 August 2024. doi:10.1038/s41591-024-03213-1
Summarised from the published abstract; every number is checked against it