Untreated Hypertension: A Powerful Risk Factor for Lobar and Nonlobar Intracerebral Hemorrhage in Whites, Blacks, and Hispanics
Authors' conclusion
Untreated hypertension confers a greater ICH risk in blacks and Hispanics relative to whites across all anatomic locations of ICH.
Study context
- Population
- Intracerebral hemorrhage (ICH) cases among whites, blacks and Hispanics with matched controls (ERICH study), 42 recruitment sitesICH cases, 1:1 matched controls
- Participants
- 958 / 880 / 766
- Comparison
- Treated and untreated hypertension vs no hypertension as risk factors for ICH, by ethnicity/race
- Whitesn = 958
- Blacksn = 880
- Hispanicsn = 766
- Outcome
- ICH risk associated with treated and untreated hypertension, overall and by location (deep, lobar, infratentorial)
Methodological detailsprospective, multicenter, matched 1:1 by age, sex, ethnicity/race and metropolitan area
- Prospective
- Multicenter
- Matched 1:1 by age, sex, ethnicity/race and metropolitan area
Main finding
As reported in the abstract
ICH risk, all locations (multivariable)
Odds ratio (95% CI)P value
Whitestreated hypertension
1.57(1.24–1.98)
P < 0.0001Blackstreated hypertension
3.02(2.16–4.22)
P < 0.0001Hispanicstreated hypertension
2.50(1.73–3.62)
P < 0.0001Whitesuntreated hypertension
8.79(5.66–13.66)
P < 0.0001Blacksuntreated hypertension
12.46(8.08–19.20)
P < 0.0001Hispanicsuntreated hypertension
10.95(6.58–18.23)
P < 0.0001Observational data: associations, not effects.
Further findings
Untreated hypertension among ICH cases
- Untreated hypertension among ICH cases: Blacks vs whites P<0.0001
- Untreated hypertension among ICH cases: Hispanics vs whites P<0.0001
Original publication
Untreated Hypertension: A Powerful Risk Factor for Lobar and Nonlobar Intracerebral Hemorrhage in Whites, Blacks, and Hispanics. Circulation. Published 13 October 2016. doi:10.
Summarised from the published abstract; every number is checked against it