Secondary analysis
Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction
- Secondary analysis of the STRONG-HF randomised trial
Authors' conclusion
Rapid uptitration of oral medications for HF and close follow-up reduce 180-day death and HF rehospitalization after AHF hospitalization independently from LVEF.
Study context
- Population
- Patients hospitalised for acute heart failure (HF) with any left ventricular ejection fraction (LVEF), not on full doses of renin-angiotensin inhibitors, beta-blockers and MRAs
- Participants
- 1,078 patients
- Comparison
- High-intensity care vs usual care, by baseline LVEF
- Primary endpoint
- HF rehospitalisation or all-cause death
- Follow-up
- Day 180
Primary result
As reported in the abstract
HF rehospitalisation or all-cause death, by LVEF
LVEF ≤40%
731 (68%)
LVEF >40%
347 (32%)
Further findings
EQ-5D visual analog scale change, by LVEF · baseline to day 90
- Mean difference between arms slightly greater at higher LVEF values, with no interaction
- interaction P = 0.358
Safety
Serious adverse events
- Independent from LVEF
Original publication
Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction. J Am Coll Cardiol. Published 6 June 2023. doi:10.1016/j.jacc.2023.03.426
Summarised from the published abstract; every number is checked against it