Heart failure & cardiomyopathies
Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices
Authors' conclusion
Patients with LVAD managed with CardioMEMS with a significant reduction in PAD at 6 months showed improvements in 6-minute walk distance. Maintaining PAD <20 mm Hg was associated with fewer heart failure hospitalizations. Hemodynamic-guided management of patients with LVAD with CardioMEMS is feasible and may result in functional and clinical benefits.
Study context
- Population
- Patients supported with HeartMate II or HeartMate 3 left ventricular assist devices (LVADs) with CardioMEMS PA sensorsPatients supported with HeartMate II 52 · or HeartMate 3 49
- Exposure
- CardioMEMS hemodynamic-guided management in LVAD patients: responders vs nonresponders (PAD reduction)
- Outcome
- Feasibility and clinical utility of CardioMEMS HF system: PA pressure, 6-minute walk distance, quality of life (EQ-5D-5 L), HF hospitalization rates
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
PAD from baseline to 6 months
| Group | Value | P (within group) |
|---|---|---|
| R | 21.5-16.5 mm Hg | P<0.001 |
| NR | 18.0-20.3 | P=0.002 |
Value
R21.5-16.5 mm Hg
NR18.0-20.3
P (within group)
RP<0.001
NRP=0.002
Observational data: associations, not effects.
Further findings
| Outcome | R | P value |
|---|---|---|
| 6-minute walk distance · 6 months | 266 versus 322 meters | |
| P (within group) | P=0.025 | |
| HF hospitalization, PAD <20 vs PAD ≥20 mm Hg for more than half the time | P = 0.005 |
- HF hospitalization, PAD <20 vs PAD ≥20 mm Hg for more than half the time: PAD <20 12.0% · Average PAD 15.6 mm Hg
- HF hospitalization, PAD <20 vs PAD ≥20 mm Hg for more than half the time: PAD ≥20 mm Hg 38.9% · Average PAD 23.3 mm Hg
6-minute walk distance · 6 months
- No change in nonresponders
Original publication
Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices. Circ Heart Fail. Published 20 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →