Heart failure & cardiomyopathiesDiagnostic or prognostic study
Use of Clinical and Echocardiographic Evaluation to Assess the Risk of Heart Failure
- Prognostic cohort study with derivation and validation
- training and validation groups
- classification and regression tree analysis
Authors' conclusion
Clinical risk assessment is adequate to classify low and high HF risk. Echocardiographic evaluation reclassifies 61% of intermediate-risk patients.
Study context
- Population
- Patients with heart failure (HF) risk factors
- Participants
- 926 vs 355
- Comparison
- Clinical risk with vs without echocardiographic stage B HF (SBHF) markers
- Trainingn = 926
- Validationn = 355
- Outcome
- Incident HF
Performance
Incident HF (training group)
Hazard ratio
2.92
95% CI 1.95–4.37
P < 0.001
By group
Training
12%
Abnormal GLS
HR 2.92 (95% CI 1.95–4.37); P < 0.001
As reported in the abstract
- Normal GLS and diastolic function reclassified intermediate-risk patients into low risk (HF incidence 12%)
- 61%
Further findings
| Outcome | C-statistic (95% CI) | P value |
|---|---|---|
| New HF admission: C-statistic, ARIC score vs ARIC + echocardiographic parameters · ARIC alone 0.78 (95% CI 0.71-0.84) | 0.83 (0.77–0.88) | P = 0.027 |
- Incident HF (validation group) · 4.5 years
- 11%
Excluding known CAD
- Similar results after exclusion of patients with known CAD
Original publication
Use of Clinical and Echocardiographic Evaluation to Assess the Risk of Heart Failure. JACC Heart Fail. Published 26 July 2023. doi:10.1016/j.jchf.2023.06.014
Summarised from the published abstract; every number is checked against it