Prevention & lipidsCohort study
Use of Mediterranean diet adherence and physical activity for refining cardiovascular risk prediction in the general population - insights from the CoLaus/PsyCoLaus study
- Prospective cohort study
- population-based
Authors' conclusion
The addition of self-reported physical activity and Mediterranean diet may provide modest incremental value to improve ASCVD risk prediction in older adults beyond the traditional SCORE2-OP.
Study context
- Population
- General population, CoLaus|PsyCoLaus cohort, with Physical Activity Frequency Questionnaire (PAFQ) and MedDietScore data59% women
- Participants
- 2,587 participants
- Exposure
- SCORE2 vs SCORE2-OP
- SCORE2n = 2,348
- SCORE2-OPn = 239
- Outcome
- Improvement in 10-year first atherosclerotic cardiovascular disease (ASCVD) risk prediction (Harrell's C, calibration slope, NRI) by adding physical activity and Mediterranean diet to SCORE2/SCORE2-OP
Main finding
ASCVD risk prediction · median follow-up 9.0 years
Continuous total net reclassification improvement (NRI)
41%
95% CI 7–74%
Events by group
SCORE2
106
events
SCORE2-OP
39
events
As reported in the abstract
Observational data: associations, not effects.
Original publication
Use of Mediterranean diet adherence and physical activity for refining cardiovascular risk prediction in the general population - insights from the CoLaus/PsyCoLaus study. Eur J Prev Cardiol. Published 4 September 2026. doi:10.1093/eurjpc/zwag466
Summarised from the published abstract; every number is checked against it