Acute cardiac care & resuscitation
Use of proton pump inhibitors is associated with increased risk of out-of-hospital cardiac arrest in the general population: a nested case-control study
Authors' conclusion
PPI use is associated with an increased risk of OHCA in the general population.
Study context
- Population
- General population; Out-of-hospital cardiac arrest (OHCA) cases of presumed cardiac causes and matched non-OHCA controls46,578 cases · 232,890 controls
- Comparison
- Current or past PPI use vs non-use
- Outcome
- OHCA (odds of OHCA)
Methodological detailsnationwide, age/sex/OHCA-date-matched controls, conditional logistic regression
- Nationwide
- age/sex/OHCA-date-matched controls
- Conditional logistic regression
Main finding
As reported in the abstract
OHCA
Each group vs non-useOdds ratio (95% CI)
Current use
1.32(1.28–1.37)
Past use
1.01(0.98–1.04)
Observational data: associations, not effects.
Further findings
OHCA, by sex (subgroup)
- Increased odds of OHCA occurred in both sexes
OHCA, current PPI use, sensitivity analyses by comorbidity
- No registered ischaemic heart disease, OR
- 1.36 (1.31-1.41) (95% CI)
- No HF, OR
- 1.33 (1.29-1.38) (95% CI)
- No CV comorbidities, OR
- 1.84 (1.70-2.00) (95% CI)
- ORs remained elevated
OHCA, PPI use with H2-antagonists as reference
- OR vs H2-antagonists
- 1.28 (1.11-1.47) (95% CI)
- OR remained elevated
Original publication
Use of proton pump inhibitors is associated with increased risk of out-of-hospital cardiac arrest in the general population: a nested case-control study. Eur Heart J Cardiovasc Pharmacother. Published 14 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →