Arrhythmias & electrophysiologyRandomised controlled trial
Using computed tomography atrial myocardial thickness maps in cryoballoon pulmonary vein isolation: the UTMOST atrial fibrillation (AF) II randomized clinical trial
- Randomised controlled trial
Authors' conclusion
The LAWT-guided energy titration strategy improved freedom from atrial arrhythmia recurrence, compared with conventional strategy.
Study context
- Population
- Patients with paroxysmal AF refractory to anti-arrhythmic drug
- Participants
- 277 patients
- Comparison
- Left atrial wall thickness (LAWT)-guided cryoballoon PV isolation (CB-PVI) vs Empirical CB-PVI
- LAWT-guided CB-PVIn = 135
- Empirical CB-PVIn = 142reference
- Primary endpoint
- Freedom from any documented atrial arrhythmia >30 s without antiarrhythmic medication after a single ablation procedure
- Follow-up
- Mean 18.7 months
Primary result
Event-free rate (primary endpoint)
Hazard ratio
0.64
95% CI 0.42–0.99
P = 0.043
By group
LAWT-guided CB-PVI vs Empirical CB-PVI
HR 0.64 (95% CI 0.42–0.99); P = 0.043
As reported in the abstract
Further findings
Total procedure time
Safety
Complications
Complications
- No differences between the groups in complication rates
Original publication
Using computed tomography atrial myocardial thickness maps in cryoballoon pulmonary vein isolation: the UTMOST AF II randomized clinical trial. Europace. Published 25 November 2024. doi:10.1093/europace/euae292
Summarised from the published abstract; every number is checked against it