HypertensionCross-sectional study
Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension
- Cross-sectional study
- observational genetic study
- gene-by-environment interaction
Authors' conclusion
The data suggest that genetic risk in sodium and potassium pathways could be used in a precision medicine model to direct interventions more specifically in the management of hypertension.
Study context
- Population
- Genotyped individuals from the UK Biobank cohort with blood pressure (BP) and urinary electrolytes (sodium and potassium) measuredup to
- Participants
- 296,475 individuals
- Exposure
- Top 10% vs Lowest 10%
- Outcome
- Gene-by-environment interaction between urinary electrolytes and genetic scores (pharmagenic enrichment scores, conventional polygenic scores) on BP
Main finding
As reported in the abstract
SBP increase per SD in urinary sodium
P = 1.95×10-3
Observational data: associations, not effects.
Further findings
Urinary sodium × standard genome-wide polygenic score of BP
- No strong evidence of an interaction
Original publication
Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension. Circulation. Published 22 December 2023. doi:10.1161/circulationaha.123.065394
Summarised from the published abstract; every number is checked against it