Valvular & structural heart diseaseCohort study
Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After Transcatheter Edge-to-Edge Repair
- Registry-based cohort study
Authors' conclusion
In patients with FMR, elevated TMPG was consistently associated with higher risks of the primary endpoint. Mild or moderate residual MR with low TMPG was associated with more favorable prognosis
Study context
- Population
- Patients with functional mitral regurgitation (MR) after mitral transcatheter edge-to-edge repair (M-TEER), with postdischarge echocardiography
- Participants
- 2,360 patients
- Exposure
- Residual MR and transmitral mean pressure gradient (TMPG) categories after M-TEER
- MR ≤ mild and TMPG <5 mm Hgn = 1,702reference
- MR ≤ mild and TMPG ≥5 to <10 mm Hgn = 164
- Moderate MR and TMPG <5 mm Hgn = 361
- Moderate MR and TMPG ≥5 to <10 mm Hgn = 71
- MR > moderate or TMPG 10 mm Hgn = 62
- Outcome
- All-cause death or HF hospitalization
- Follow-up
- 2 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Moderate MR and TMPG <5 mm Hg vs MR ≤ mild and TMPG <5 mm Hg
1.13(0.92–1.41)
P = 0.24TMPG per 1 mm Hg incrementmultivariable analysis
1.10(1.02–1.17)
P = 0.008- Difference across the 5 groups
- P < 0.001
Observational data: associations, not effects.
Further findings
Residual MR severity (reference MR ≤ mild)
- Moderate MR not linked to higher risk; MR > moderate a significant predictor of primary endpoint
Original publication
Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After Transcatheter Edge-to-Edge Repair. J Am Coll Cardiol. Published 11 November 2025. doi:10.1016/j.jacc.2025.07.041
Summarised from the published abstract; every number is checked against it