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Heart failure & cardiomyopathiesCohort study

Utility of ECG-Vision for Surveillance of Left Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy Initiated on Mavacamten

Circ Heart FailPublished

  • single-center exploratory cohort
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Authors' conclusion

In this single-center exploratory cohort of patients with obstructive hypertrophic cardiomyopathy receiving mavacamten, ECG-Vision left ventricular demonstrated high observed sensitivity and negative predictive value for TTE-defined LVSD, although estimates were imprecise because LVSD events were infrequent. These findings support prospective multicenter validation of AI-enabled ECG as a potential adjunctive triage tool.

Study context

Population
Patients with obstructive hypertrophic cardiomyopathy initiated on mavacamten at Morristown Medical Center/Atlantic Health between June 2022 and June 2025453 paired ECG-TTE observations
Participants
147 patients
Exposure
Artificial intelligence (AI)-enabled ECG vs TTE-defined left ventricular systolic dysfunction (LVSD)

Main finding

As reported in the abstract

Baseline characteristics

mean age

65±14 years

male

44%

Observational data: associations, not effects.

Further findings

OutcomeAI-enabled ECGTTE
Diagnostic performance for LVSD at AI probability threshold of 20%
sensitivity100% (95% CI, 68%-100%)Not reported in the abstract
specificity75% (95% CI, 69%-82%)Not reported in the abstract
positive predictive value7% (95% CI, 3%-11%)Not reported in the abstract
negative predictive value100% (95% CI, 99%-100%)Not reported in the abstract
  • Diagnostic performance for LVSD at AI probability threshold of 20%: CIs accounting for repeated paired ECG-TTE observations within patients

LVSD event observations

LVSD event observations among 453 paired ECG-TTE observations
8

Area under the curve

area under the curve
0.94 (95% CI, 0.90-0.98)

Patient-level classification, AI-enabled ECG vs echo-confirmed LVSD

concordant
127 of 147 patients (86%)
inconclusive
17 of 147 (12%)
discordant
3 of 147 (2%)

Original publication

Utility of ECG-Vision for Surveillance of Left Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy Initiated on Mavacamten. Circ Heart Fail. Published 10 August 2026. doi:10.1161/circheartfailure.126.014177
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it