Heart failure & cardiomyopathies
Utility of Heart Failure with Preserved Ejection Fraction (HFpEF) Diagnostic Scores to Stratify Cardiac Reserve Among Patients With Dyspnea
Authors' conclusion
The HFpEF scores stratify the extent of cardiac dysfunction, hemodynamic severity, and functional limitation in a broad cohort of individuals with chronic dyspnea, across the overall cohort and within individuals with or without HFpEF.
Study context
- Population
- Patients undergoing invasive cardiopulmonary exercise testing for unexplained dyspnea (HFpEF or noncardiac dyspnea)902 HFpEF, 228 noncardiac dyspnea
- Participants
- 1,130 patients
- Exposure
- High vs intermediate vs low HFpEF probability by HFpEF-ABA score
- Lown = 91reference
- Intermediaten = 559
- Highn = 480
- Outcome
- Cardiac structure, function and cardiopulmonary reserve by HFpEF score
Main finding
As reported in the abstract
Cardiac structure, function, hemodynamic and cardiopulmonary indices by HFpEF-ABA score
- High HFpEF-ABA score: more severe structural and functional abnormalities across virtually all morphological, functional, hemodynamic and cardiopulmonary indices
Observational data: associations, not effects.
Further findings
H2FPEF and HFA-PEFF scores; HFpEF-only and noncardiac dyspnea-only analyses
- Similar findings
Original publication
Utility of HFpEF Diagnostic Scores to Stratify Cardiac Reserve Among Patients With Dyspnea. JACC Heart Fail. Published 5 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it