Heart failure & cardiomyopathiesCross-sectional study
Utility of Heart Failure with Preserved Ejection Fraction (HFpEF) Diagnostic Scores to Stratify Cardiac Reserve Among Patients With Dyspnea
- Cross-sectional study
Authors' conclusion
The HFpEF scores stratify the extent of cardiac dysfunction, hemodynamic severity, and functional limitation in a broad cohort of individuals with chronic dyspnea, across the overall cohort and within individuals with or without HFpEF.
Study context
- Population
- Patients undergoing invasive cardiopulmonary exercise testing for unexplained dyspnea (HFpEF or noncardiac dyspnea)902 HFpEF, 228 noncardiac dyspnea
- Participants
- 1,130 patients
- Exposure
- High vs intermediate vs low HFpEF probability by HFpEF-ABA score
- Lown = 91reference
- Intermediaten = 559
- Highn = 480
- Outcome
- Cardiac structure, function and cardiopulmonary reserve by HFpEF score
Main finding
As reported in the abstract
Cardiac structure, function, hemodynamic and cardiopulmonary indices by HFpEF-ABA score
- High HFpEF-ABA score: more severe structural and functional abnormalities across virtually all morphological, functional, hemodynamic and cardiopulmonary indices
Observational data: associations, not effects.
Further findings
H2FPEF and HFA-PEFF scores; HFpEF-only and noncardiac dyspnea-only analyses
- Similar findings
Original publication
Utility of HFpEF Diagnostic Scores to Stratify Cardiac Reserve Among Patients With Dyspnea. JACC Heart Fail. Published 5 August 2025. doi:10.1016/j.jchf.2025.102526
Summarised from the published abstract; every number is checked against it