Coronary disease & ACSSecondary analysis
Validated 1-year mortality prediction in patients with three-vessel disease undergoing contemporary percutaneous coronary intervention: insights from the Multivessel TALENT trial
- post hoc analysis of the Multivessel TALENT trial
- 20 imputed datasets
- intercept-and-slope recalibration
- decision curve analysis
Authors' conclusion
In contemporary PCI for 3VD, the LCSS showed moderate discrimination for 1-year all-cause mortality while overestimating its absolute risk. Recalibration improved agreement with observed risk in this cohort and may inform future validation and model refinement.
Study context
- Population
- Patients with three-vessel coronary artery disease (3VD) undergoing contemporary percutaneous coronary intervention (PCI)
- Participants
- 1,548 enrolled patients
- Comparison
- core and extended logistic clinical SYNTAX Score (LCSS) for predicting 1-year all-cause mortality, compared with the anatomical and functional SYNTAX Score
Primary result
As reported in the abstract
All-cause mortality · 1 year
patients who had died, of 1548 enrolled
46 (3.0%)
Further findings
Pooled AUC
| Outcome | LCSS core model | LCSS extended model | anatomical SYNTAX Score | functional SYNTAX Score |
|---|---|---|---|---|
| Discrimination for 1-year all-cause mortality (pooled AUC) | 0.716 | 0.744 | 0.629 | 0.632 |
Calibration
- LCSS models systematically overestimated absolute risk, although observed mortality increased across predicted-risk quintiles
Decision curve analysis
- positive net benefit for the original and recalibrated LCSS models across threshold probabilities
- 1-10%
- numerically higher net benefit for the recalibrated extended model across much of the evaluated threshold range
Original publication
Validated 1-year mortality prediction in patients with three-vessel disease undergoing contemporary percutaneous coronary intervention: insights from the Multivessel TALENT trial. Eur Heart J Qual Care Clin Outcomes. Published 28 July 2026. doi:10.1093/ehjqcco/qcag122
Summarised from the published abstract; every number is checked against it