Validation of the European SCORE2 models in a Canadian primary care cohort
Authors' conclusion
The performance of SCORE2 to predict ASCVD risk in Canada varied by age group and depended on whether regional calibration was applied.
Study context
- Population
- Primary care cohort with routinely collected EMR data, Ontario, Canada, 2010–2014
- Participants
- 57,409 vs 9,885
- Comparison
- SCORE2-YP and SCORE2-OP, uncalibrated vs low-risk region recalibrated
- SCORE2-YPn = 57,409
- SCORE2-OPn = 9,885
- Outcome
- Validity (discrimination and calibration) of SCORE2 for predicting atherosclerotic cardiovascular disease (ASCVD)
- Follow-up
- 5 years
Methodological detailsretrospective cohort, external validation, primary care EMR data
- Retrospective cohort
- External validation
- Primary care EMR data
Performance
As reported in the abstract
Five-year ASCVD prediction performance
| Test or model | C-statistic, women | C-statistic, men | Uncalibrated: overestimated risk, women | Uncalibrated: underestimated risk, men | Low-risk recalibrated: overestimated risk, women | Low-risk recalibrated: overestimated risk, men | Uncalibrated: overestimated risk, both sexes |
|---|---|---|---|---|---|---|---|
| SCORE2-YP | 0.74 | 0.69 | 17% | 2% | 100% | 36% | |
| SCORE2-OP | 0.64 | 0.62 | 60% | 13% | >100% |
C-statistic, women
SCORE2-YP0.74
SCORE2-OP0.64
C-statistic, men
SCORE2-YP0.69
SCORE2-OP0.62
Uncalibrated: overestimated risk, women
SCORE2-YP17%
SCORE2-OP— not stated in the abstract
Uncalibrated: underestimated risk, men
SCORE2-YP2%
SCORE2-OP— not stated in the abstract
Low-risk recalibrated: overestimated risk, women
SCORE2-YP100%
SCORE2-OP60%
Low-risk recalibrated: overestimated risk, men
SCORE2-YP36%
SCORE2-OP13%
Uncalibrated: overestimated risk, both sexes
SCORE2-YP— not stated in the abstract
SCORE2-OP>100%
Original publication
Validation of the European SCORE2 models in a Canadian primary care cohort. Eur J Prev Cardiol. Published 8 November 2023. doi:10.
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