Pulmonary vascular disease & thromboembolismCohort study
Value of right heart haemodynamics for risk stratification of patients with pulmonary arterial hypertension at follow-up
- multicentre cohort
- 11 Italian centres
Authors' conclusion
In prevalent patients with PAH, a good haemodynamic profile predicts better survival in intermediate-risk patients and, importantly, a lower CW rate in low-risk patients.
Study context
- Population
- Incident patients with PAH enrolled between 2005 and 2021 who had a first follow-up right heart catheterization within 6–12 months of diagnosis, categorized by the noninvasive ESC/ERS 4-strata risk stratification modellow risk 162 · intermediate-low risk 240 · intermediate-high risk 339 · high risk 28
- Exposure
- good haemodynamic subgroup compared with the poor haemodynamic subgroup, within each noninvasive risk category
Main finding
As reported in the abstract
Survival and CW rate, low-risk patients
- survival was similar
- good haemodynamic profile vs poor haemodynamic profile: P = 0.033
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Survival and CW rate, intermediate-low risk patients — good haemodynamic profile vs poor haemodynamic profile · survival significantly better in good haemodynamic subgroup | P = 0.028 |
| Survival and CW rate, intermediate-low risk patients — good haemodynamic profile vs poor haemodynamic profile · CW rate significantly better in good haemodynamic subgroup | P = 0.011 |
| Survival and CW rate, intermediate-high risk patients · survival significantly better in good haemodynamic subgroup | P = 0.015 |
Survival and clinical worsening (CW) rate, intermediate-high risk patients
- the CW rate was similar
Haemodynamic profile, high-risk group
- patients with a good haemodynamic profile
- 1 out of 28
Follow-up
- Median follow-up
- 3.7 years (interquartile range 1.2-6.8) months
Original publication
Value of right heart haemodynamics for risk stratification of patients with pulmonary arterial hypertension at follow-up. ESC Heart Fail. Published 17 February 2026. doi:10.1093/eschf/xvaf012
Summarised from the published abstract; every number is checked against it